LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria Descriptor: (2~{R},4~{R})-4-[[(2~{S},4~{S})-4-fluoranylpyrrolidin-2-yl]carbonylamino]-1-(2-methylpropanoyl)-~{N}-[[4-(2-phenylethynyl)phenyl]methyl]pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION Authors: Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. Deposit date: 2021-08-17 Release date: 2022-09-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.45 Å) Cite: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published以氟脯氨酸为新型锌结合基团的LpxC抑制剂：可作为一类针对多重耐药革兰氏阴性菌的新型抗生素 描述符：(2R,4R)-4-[[(2S,4S)-4-氟吡咯烷-2-基]甲酰胺基]-1-(2-甲基丙酰基)-N-[[4-(2-苯乙炔基)苯基]甲基]吡咯烷-2-甲酰胺、UDP-3-O-酰基-N-乙酰葡糖胺脱乙酰酶、锌离子 作者：Ryan M.D、Pallin T.D、Lamers M.B.A.C、Leonard P.M. 提交日期：2021-08-17 发布日期：2022-09-07 最后修改日期：2024-02-07 检测方法：X射线衍射（分辨率2.45埃） 引用文献：《以氟脯氨酸为新型锌结合基团的LpxC抑制剂：可作为一类针对多重耐药革兰氏阴性菌的新型抗生素》（待发表）