Infantile amnesia, the inability to recall episodic memories formed during early childhood, is a hallmark of postnatal brain development. Yet the underlying mechanisms remain poorly understood. This w

Figshare2026-01-20 更新50

CSF-1 and IL-34 drive distinct microglial programs in the brain tissue

胶质细胞调控

神经免疫学

Bulk RNA sequencing of FACS sorted primary murine microglia from WT mixed glial cultures isolated from P2-3 forebrain and cerebellum, stimulated with either IL-34 or CSF-1 Overall design: Microglia is

NIAID Data Ecosystem20

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

阿尔茨海默病机制

胶质细胞调控

The hemizygous R47H variant of TREM2, a microglia-specific gene in the brain, increases risk for late-onset Alzheimer's disease (AD). Using transcriptomic analysis at the single-nuclei level from brai

NIAID Data Ecosystem50

Investigating effect of TMEM184B mutation on hippocampal gene expression in 5 month and 15 month old mice

海马神经元转录组

神经功能基因表达

The objective of this study was to determine whether TMEM184B influenced the expression of genes important for neuronal function or memory. We isolated hippocampus tissue from 3-4 mice of wild type or

Alliance of Genome Resources40