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The RNAPII-CTD Maintains Genome Integrity Through Inhibition of Retrotransposon Gene Expression and Transposition

ChEBI2015-11-28 更新2026-07-12 收录

基因组稳定性

逆转录转座子抑制剂

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-3906 数据链接链接失效反馈

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The RNAPII-CTD Maintains Genome Integrity Through Inhibition of Retrotransposon Gene Expression and Transposition

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创建时间：

2015-11-28

表观遗传调控

基因组稳定性

Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans, and has been implicated in many important biological processes including cell differentiation and reprogramming. Germlin

NIAID Data Ecosystem80

Expansions and Contractions in a Tandem Repeat Induced by Double-Strand Break Repair

基因组稳定性

DNA损伤修复

Repair of a double-strand break (DSB) in yeast can induce very frequent expansions and contractions in a tandem array of 375-bp repeats. These results strongly suggest that DSB repair can be a major s

PubMed Central60

Whole-genome sequencing analysis of CRISPR-tolerant mutants. Escherichia coli

CRISPR系统

基因组稳定性

To investigate whether ISs transpositions into cas genes could potentially lead to concurrent transpositions into other genomic loci or induce genomic rearrangements and instability, we performed whol

NIAID Data Ecosystem40

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress [ChIP-seq]

基因组稳定性

RNA调控机制

Repetitive sequences derived from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genome integrity. Repetitive elements are often found in heterochromatin; h

干细胞与再生医学数据中心2022-02-20 更新60

BLM prevents instability of structure-forming DNA sequences at common fragile sites

基因组稳定性

DNA修复

Genome instability often arises at common fragile sites (CFSs) leading to cancer-associated chromosomal rearrangements. However, the underlying mechanisms of how CFS protection is achieved is not well

Figshare2018-12-11 更新50

The RNAPII-CTD Maintains Genome Integrity Through Inhibition of Retrotransposon Gene Expression and Transposition

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