Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF362 inhibitor

Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF362 inhibitor Descriptor: GLYCINE, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid, ... Authors: Katinas, J.M, Dann III, C.E. Deposit date: 2022-12-20 Release date: 2023-09-06 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. J.Med.Chem., 66, 2023人源线粒体丝氨酸羟甲基转移酶（SHMT2）与磷酸吡哆醛（PLP）、甘氨酸及AGF362抑制剂形成的复合物。配体描述：甘氨酸、N-甘氨酸-[3-羟基-2-甲基-5-膦酰氧基甲基-吡啶-4-基甲烷]、N-{4-[4-(2-氨基-4-氧代-3,4-二氢-5H-吡咯并[3,2-d]嘧啶-5-基)丁基]-3-氟噻吩-2-羰基}-L-谷氨酸等。作者：Katinas, J.M.、Dann III, C.E.。入库日期：2022-12-20；发布日期：2023-09-06；最后更新日期：2024-02-07。检测方法：X射线衍射（分辨率2.47 Å）。引用文献：《胞质与线粒体中转运特异性多靶点一碳代谢抑制剂的基于结构设计》，《药物化学杂志》（J. Med. Chem.），2023年，第66卷。