Modified NSG mice reveal the function of SPARC in leukemia
收藏NIAID Data Ecosystem2026-03-10 收录
官方服务：
资源简介：
This data corresponds to on-target and off-target CRISPR/Cas9 editing observed in engineered NSG mice at the SPARC locus.
应用场景：
创建时间：
2017-10-19
相关数据集
The Adult T-Cell Leukemia/Lymphoma Cell Line KK1 +/- RhoH Reconstitution
The adult T-cell leukemia/lymphoma cell line KK1 with low RhoH expression was stably transfected with either an empty expression vector or this same vector expressing human RhoH. The transcriptomes of
NIAID Data Ecosystem50
Transcriptome upon PDXK knock-out in mouse and human leukemic cells
To study transcriptomic changes upon PDXK knock-out in mouse and human leukemic cells For RNA-seq analysis of the transcriptional profiles of mouse MLLAF9-NrsG12D and human MOLM13 leukemic cells trans
NIAID Data Ecosystem30
SETD2 Mutations Do Not Contribute to Clonal Fitness in Response to Chemotherapy in Childhood B Acute Lymphoblastic Leukemia (RNA-Seq). SETD2 Mutations Do Not Contribute to Clonal Fitness in Response to Chemotherapy in Childhood B Acute Lymphoblastic Leukemia (RNA-Seq)
To investigate the impact of SETD2 mutations on clonal fitness in B actue lymphoblastic leukemia we generated cells lines with SETD KO using CRISPR/Cas9 system. We then performed phenotypic based assa
NIAID Data Ecosystem30
Transcriptomic analysis of ETV6/RUNX1 KO lymphoid cell line generated by CRISPR/Cas9 showed a distinct expression signature and a deregulation of its downstream signaling genes
The gene expression profile of E/R KO clones versus REH cells and controls clones, analysed by total RNA-sequencing, showed a total of 342 genes differentially expressed (q<0.05), 182 upregulated and
NIAID Data Ecosystem40
Leukemia associated mutant Wilms' tumour gene 1 protein promotes expansion of human hematopoietic progenitor cells. Homo sapiens
Analysis of gene expression levels in hematopoietic progenitor cells retrovirally transduced with full-length WT1(+/-) or a WT1-mutant lacking zinc-finger, WT1(delZ) cultured in vitro for 14 days. The
NIAID Data Ecosystem30
