Synthesis and Recognition Properties of Cucurbit[8]uril Derivatives
收藏NIAID Data Ecosystem2026-03-09 收录
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A building block approach to the synthesis of Me4CB[8] and Cy2CB[8] by condensation of glycoluril hexamer 1 with bis(cyclic ethers) 2 is reported. X-ray crystallography demonstrates that the equatorial substitution results in an ellipsoidal cavity. Me4CB[8] and Cy2CB[8] display enhanced aqueous solubility and retain the ability to bind to guests (3–9) typical of unsubstituted CB[8]. The higher inherent solubility of Me4CB[8] allowed it to be used as a solubilizing excipient for insoluble drugs.
创建时间：
2016-02-12
