The identification of miRNA targets by Ago2-CLIP methods has provided major insights into the biology of this important class of non-coding RNAs. However, these methods are technically challenging and

NIAID Data Ecosystem20

Role of GADD45 proteins in embryonic stem cells and their derivatives. Mus musculus

干细胞功能基因组学

基因敲除转录组

We generated Gadd45a,b,g triple-knockout mouse embryonic stem cells and performed RNA-seq expression profiling under six different conditions of cell culture and in vitro differentiation. Overall desi

NIAID Data Ecosystem60

Comparison of brown adipose tissue (BAT) gene expression between Letmd1 KO and wild-type control mice housed at 30C or 7C for 3 weeks.

棕色脂肪组织产热调节

基因敲除转录组

We identified Letm1 domain containing 1 (Letmd1) as a candidate regulator of BAT thermogenesis. We generated Letmd1 KO mice, raised at thermoneutral or cold conditions, and performed RNA-sequencing in

Alliance of Genome Resources20

RNA-seq of mouse embryonic stem cells with Ronin/Thap11 knockout

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