Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

Detection Capabilities for the Therascreen EGFR Mutation Test kit versus Direct Sequencing.

EGFR突变检测

分子诊断

CI, confidence interval.PPV, positive predictive value.NPV, negative predictive value.

Figshare2015-12-02 更新40

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer

癌症靶向治疗

RAS信号通路抑制

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kina

Protein Data Bank Japan2024-07-10 更新60

Design and Optimization of Novel Benzimidazole- and Imidazo[4,5‑ b ]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities

激酶抑制剂开发

癌症靶向治疗

The ATM kinase is a promising target in cancer treatment as an important regulator of the cellular response to DNA double-strand breaks. In this work, we present a new class of specific benzimidazole-

NIAID Data Ecosystem40

The changes of EGFR mutations after TKI targeted therapy.

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