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Homeobox protein NKX2-3 modulates lymphocyte dynamics and promotes B-cell lymphomagenesis

ChEBI2016-07-22 更新2026-07-12 收录

淋巴瘤发生机制

NKX2-3蛋白功能研究

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-49356 数据链接链接失效反馈

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资源简介：

Homeobox protein NKX2-3 modulates lymphocyte dynamics and promotes B-cell lymphomagenesis

应用场景：

创建时间：

2016-07-22

淋巴瘤发生机制

转录因子调控网络

Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative genetic lesions have been discovered and their functi

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Pre-neoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma [scRNA-seq]

淋巴瘤发生机制

肿瘤前体突变

Normal-cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B-lymphocytes prior to lymphoma remains uncertain. We sequenced multiple st

NIAID Data Ecosystem70

Smc3 regulates B-cell transit through germinal centers and restricts their malignant transformation (HiC)

细胞分化调控

淋巴瘤发生机制

During the germinal center (GC) reaction, B-cells undergo extensive redistribution of cohesin complex and 3D re-organization of their genomes. Yet, the significance of cohesin and architectural progra

NIAID Data Ecosystem20

Unrestricted SUMOylation drives lymphomagenesis

SUMOylation修饰

淋巴瘤发生机制

Unrestricted SUMOylation drives lymphomagenesis Overall design: Unrestricted SUMOylation drives lymphomagenesis

NIAID Data Ecosystem90

Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors

淋巴瘤发生机制

V(D)J重组与DNA修复

Defects in the nonhomologous end-joining (NHEJ) pathway of double-stranded DNA break repair severely impair V(D)J joining and selectively predispose mice to the development of lymphoid neoplasia. This

PubMed Central20

Homeobox protein NKX2-3 modulates lymphocyte dynamics and promotes B-cell lymphomagenesis

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