RNA-seq of whole blood from progressing SSc-ILD patients

To identifying new blood derived prognostic biomarkers of lung disease progression in systemic sclerosis patients, we performed RNA-seq on whole blood from progressing SSc-ILD patients and controls enrolled in the FaSScinate clinical trial or an independent cohort. Overall design: Comparative gene expression profiling to identify genes associated with disease progression between stable and progressing patients based on change in percent predicted FVC or HRCT.