Nampt mutations Identified in Resistant Cell Lines.

Cell lines that were selected to grow in the presence of 100 fold the parental IC50 for GNE-618. NA indicates whether the cell line was selected in the presence or absence of 10 uM nicotinic acid. NAPRT1 status did not change as a result of selection for GNE-618 resistance.Nampt mutations Identified in Resistant Cell Lines.本数据集所涵盖的细胞系均为经筛选后可在浓度相当于亲本细胞对GNE-618半数抑制浓度（IC50）100倍的培养条件下存活增殖的细胞系。其中，标注"NA"用于说明该细胞系是在添加10 μM烟酸（nicotinic acid）还是不含烟酸的环境中完成筛选的。针对GNE-618耐药性的筛选并未改变NAPRT1的基因状态。本数据集同时包含在耐药细胞系中鉴定得到的Nampt突变信息。