Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction Descriptor: 5-cyclopropyl-1-[3-[(2,3,5,6-tetramethylphenyl)sulfonylamino]phenyl]pyrazole-4-carboxylic acid, DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, ... Authors: Narayanan, D, Bach, A, Gajhede, M. Deposit date: 2020-06-16 Release date: 2021-04-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds. J.Med.Chem., 64, 2021与Keap1-Nrf2蛋白质相互作用小分子抑制剂结合的Keap1 kelch结构域（Kelch样ECH相关蛋白1，Kelch-like ECH-associated protein 1） Descriptor：5-环丙基-1-[3-[(2,3,5,6-四甲基苯基)磺酰氨基]苯基]吡唑-4-羧酸、二甲基亚砜（DIMETHYL SULFOXIDE）、Kelch样ECH相关蛋白1（Kelch-like ECH-associated protein 1）…… Authors：Narayanan D、Bach A、Gajhede M Deposit date：2020-06-16 Release date：2021-04-14 Last modified：2024-01-24 Method：X射线衍射（X-RAY DIFFRACTION），分辨率1.6埃（1.6 Å） Cite：《将非共价Kelch样ECH相关蛋白1（Keap1）抑制剂拆解为片段以重构新型强效化合物》，《药物化学杂志》（J.Med.Chem.），第64卷，2021年