The vascular tumor model.
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It consists of a collection of representative units (RUs), each a cylinder of radius r0 centered on a cylindrical blood vessel of radius rb, which serves as the source of the administered immunotoxin. The values of rb and r0 used were 11 and 50 µm, respectively. Expanded view: The immunotoxin molecules, each represented as a small orange circle with a blue arrowhead, leave from blood vessel by permeating through the blood vessel wall into the extra-cellular space of the tumor tissue, diffuse in this space, bind to surface antigen molecules, and then become internalized by endocytosis.
本数据集包含一组代表性单元(representative units, RUs),每个单元均为以半径为rb的圆柱形血管为中心、半径为r0的圆柱体,该血管为给药免疫毒素的来源。本次实验所用的rb与r0取值分别为11与50微米。展开说明:免疫毒素分子(immunotoxin molecules)每个均被描绘为带有蓝色箭头的橙色小圆,从血管中渗出并穿过血管壁进入肿瘤组织的细胞外间隙,在该间隙内扩散,结合表面抗原分子,随后通过内吞作用被内化。



