SWHP03 A novel pig model of Helicobacter pylori infection demonstrating Th1 and cytotoxic T cell responses

This time-course study assesses systemic and local immune responses in pigs challenged with a European and African strain of Helicobacter pylori. Immunophenotype and gene expression was assessed in peripheral blood mononuclear cells every week over a course of 2 months. At the end of the study animals were euthanized and local immune responses as well as histological changes and bacterial burden were assessed.