Characterisation of tumour mutation status and xenograft tumours.

1: p53 staining is scored as hot spots where 5 = 30–60% and 6 = 60–100%, and the staining intensity is given in brackets (1 = weak, 2 = medium and 3 = strong).2: S100A4 is scored as % positive cells where 1 = 1–4%, 2 = 5–9%, 3 = 10–14%, 4 = 15–49%, 5≥50%, and the staining intensities is given in brackets (1 = weak, 2 = medium and 3 = strong).3: Time in weeks required for the implanted patient material to reach 10 mm.4:Time in weeks required for the xenograft passage to reach 10 mm for F3 and forward.1: p53染色以热点区域进行评分，其中评分5对应阳性细胞占比30%~60%，评分6对应60%~100%；染色强度以括号标注（1=弱染色，2=中等强度染色，3=强染色）。2: S100A4以阳性细胞百分比进行评分，其中1对应1%~4%，2对应5%~9%，3对应10%~14%，4对应15%~49%，5对应≥50%；染色强度以括号标注（1=弱染色，2=中等强度染色，3=强染色）。3: 植入的患者来源组织长至直径10 mm所需的时间（单位：周）。4: F3代及后续传代的异种移植瘤长至直径10 mm所需的时间（单位：周）。