Haplotype-associated lung tumor modifier (Halt) loci identified by haplotype analysis, using the 140K BROAD SNP panel.

aPosition of the central SNP, in mega bases (Mb) based on NCBI m37 mouse assembly.bGlobal -log P is the minus logarithm of the p-value for the haplotype sliding window (window size: 3-SNPs).cUI, urethane-induced lung tumor incidence, UM, urethane-induced lung tumor multiplicity.dAt each Halt locus, the intercrosses whose parental strains carry different alleles, and that have herein been analyzed, are indicated. AHF2, (A/J×C3H/He)F2; CHF2, (BALB/c×C3H/He)F2; CWF2, (BALB/c×SWR/J)F2.a. 核心单核苷酸多态性（Single Nucleotide Polymorphism, SNP）的位置，单位为兆碱基（Mb），基于NCBI m37小鼠基因组组装版本。 b. 全局 -log P值为单体型滑动窗口（窗口大小：3个SNP）对应的p值的负对数。 c. UI指氨基甲酸乙酯（urethane）诱导的肺肿瘤发生率，UM指氨基甲酸乙酯诱导的肺肿瘤多发数。 d. 在每个Halt基因座（locus）上，将亲本品系携带不同等位基因且本文已开展分析的互交系予以标注。其中AHF2代表(A/J×C3H/He)F2，CHF2代表(BALB/c×C3H/He)F2，CWF2代表(BALB/c×SWR/J)F2。