Antibody response of CD46-IFNAR mice to immunization with MV-EDIII or MV-EDIII-ectoM.

aCD46-IFNAR mice were inoculated intraperitoneally (i.p.) twice with 105 TCID50 of MV, MV-EDIII or MV-EDIII-ectoM at one month of interval (6 mice/group). bTwo months after the last immunization, mice were inoculated with 107 FFU of DV1 FGA/NA d1d and sera were analyzed 3 weeks after. cAntibody titers were determined by ELISA on pooled heat-inactivated sera collected one month after immunization and DV inoculation. dFRNT50 represents the highest serum dilution that reduced the number of DV focus-forming units (FFU) on Vero cells by at least 50% and eFRNT75 by at least 75%.a. aCD46-IFNAR小鼠以1个月为间隔（每组6只），经腹腔内（i.p.）接种10^5 半数组织培养感染剂量（TCID50）的麻疹病毒（MV）、MV-EDIII或MV-EDIII-ectoM，共接种2次。b. 末次免疫后2个月，使用10^7 蚀斑形成单位（FFU）的DV1 FGA/NA d1d攻毒小鼠，并于攻毒后3周采集血清进行检测分析。c. 采用酶联免疫吸附试验（ELISA）对免疫后1个月及登革病毒（DV）攻毒后采集的混合热灭活血清的抗体效价进行测定。d. FRNT50指可使Vero细胞上DV蚀斑形成单位（FFU）数量减少至少50%的最高血清稀释度；e. FRNT75则指可使该指标减少至少75%的最高血清稀释度。