Internode genes that fall in the 95% percentile of T2D association gene scores based on DIAGRAM meta-analysis using MAGENTA, and putative associations with T2D-related traits.

Associations were looked-up in GWAS meta-analyses from the MAGIC, GIANT and ICBP consortiums for SNPs within 500 kb from the internode gene boundaries.*upregulated in our chronic insulin treatment (fold change = 1.4; FDR = 0.004) and in the Dor RNAi experiment (fold change = 1.33; FDR = 0.1).**Chromosome position based on genome build 36 (hg18).#Within the high confidence internode set.BMI: Body Mass Index; HDL: High Density Lipoprotein; LDL: Low Density Lipoprotein; 2 hrGluc: 2 hours glucose challenge; TC: total Cholesterol; WHR: Waist to Hip Ratio; TG: Triglycerides; DBP:Diastolic Blood Pressure; SBP: Systolic Blood Pressure; HbA1C: Glycaeted Hemoglobin; FastGluc: Fasting Glucose levels; HGNC: HUGO Gene Nomenclature committee.本研究针对基因间区边界上下游500 kb范围内的单核苷酸多态性（Single Nucleotide Polymorphism，SNP），在MAGIC、GIANT及ICBP联盟的全基因组关联研究（Genome-Wide Association Study，GWAS）荟萃分析中检索其关联信息。*该基因在本团队的慢性胰岛素处理实验中呈上调表达（折叠变化=1.4；错误发现率（False Discovery Rate，FDR）=0.004），同时在Dor RNA干扰（RNA interference，RNAi）实验中亦呈上调表达（折叠变化=1.33；FDR=0.1）。**染色体位置基于人类基因组组装版本36（hg18）标注。#该基因属于高置信度基因间区集合。相关术语说明如下：BMI（身体质量指数，Body Mass Index）、HDL（高密度脂蛋白，High Density Lipoprotein）、LDL（低密度脂蛋白，Low Density Lipoprotein）、2 hrGluc（2小时葡萄糖负荷试验，2 hours glucose challenge）、TC（总胆固醇，total Cholesterol）、WHR（腰臀比，Waist to Hip Ratio）、TG（甘油三酯，Triglycerides）、DBP（舒张压，Diastolic Blood Pressure）、SBP（收缩压，Systolic Blood Pressure）、HbA1C（糖化血红蛋白，Glycaeted Hemoglobin）、FastGluc（空腹血糖，Fasting Glucose levels）、HGNC（人类基因命名委员会，HUGO Gene Nomenclature committee）