Microarray analysis of embryonic E12.5 mouse gonads from control male, female and Amh; Inhbb dKO males

Fate determination and maintenance of fetal testes in most mammals occur cell autonomously as a result of the action of key transcription factors in Sertoli cell. In the mouse testis AMH and Activin B are required for the maintenance of Sertoli cell fate. By E12.5, the testis of the dKO male are comparable with the conrol testis as Amh and Activin B are not required for the initial testis differentiation. By E15.5 Sertoli cells at the testis poles in the dKO transdifferentiate into granulosa cells. We compared the transcriptional profile of control testis, control ovaries and dKO testis (Amh-/-; Inhbb-/-) testis at E12.5