Testis-to-ovary reprogramming and testis regression after ablation of Sox9 in Sox8-/- mice. Testis-to-ovary reprogramming and testis regression after ablation of Sox9 in Sox8-/- mice
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We used two Sertoli-cell-specific Cre lines: Wt1-CreERT2 and Sox9-CreERT2, to induce Sox9 ablation on a Sox8 -/- background in the adult testis. Sox9/8 double KO testes undergo testis-to-ovary genetic reprogramming and Sertoli-to-granulosa cell transdifferentiation.
创建时间：
2016-06-09
