Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination

The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.本研究开发了首例以地球储量丰富的钴为催化剂的高支化区域选择性且对映选择性的烯丙基胺化反应，可实现带有烷基取代基的外消旋支化烯丙基碳酸酯与芳香胺、脂肪胺两类底物的转化。该反应可在温和反应条件下，以高收率、完全支化区域选择性以及优异的对映选择性（通常可达99% ee）快速制备烯丙基胺类化合物。