Genetic Studies in the Hutterites. Genetic Studies in the Hutterites

We conducted genetic studies of disease-associated quantitative phenotypes, including microbiome and gene expression studies, and common diseases, such as asthma and Alzheimer's disease, by genotyping and/or sequencing in the Hutterites, a founder population of European descent. The Hutterites who have participated in our studies live on communal farms in South Dakota and are related to each other through multiple lines of descent in a 3,657-person, 13-generation pedigree with 64 founders. The small number of founding genomes reduces genetic heterogeneity whereas their communal lifestyle ensures that non-genetic factors are remarkably uniform between individuals. Our sample includes >1,600 subjects who have participated in our studies of fertility (since 1982), asthma, cardiovascular... (for more see dbGaP study page.)本研究针对欧洲血统的创始人种群——哈特派（Hutterites），通过基因分型及/或测序技术，开展了疾病相关数量性状表型（包括微生物组与基因表达研究）及哮喘、阿尔茨海默病等常见疾病的遗传学研究。参与本研究的哈特派成员定居于美国南达科他州的集体农庄，彼此间通过多条世系相连，形成一套包含64位奠基者、共计3657名成员、跨越13代的家系谱系。该种群奠基者基因组数量有限，降低了遗传异质性；同时其集体生活模式确保了个体间的非遗传因素高度均一。本研究队列纳入了超过1600名受试者，他们均参与了自1982年启动的生育力、哮喘及心血管……相关研究（更多详情请查阅dbGaP研究页面）。