16S rRNA gene (V1-V2) amplicon sequences from patients with Hirschsprung-associated enterocolitis

Despite effective surgery to restore gut motility, neonates with Hirschsprung Disease (HSCR) remain at high risk for developing a potentially life-threatening enterocolitis with unknown etiology. Several recent studies have suggested potential involvement of gut microbiota in the underlying pathogenesis of Hirschsprung-associated enterocolitis (HAEC). These data employed the Illumina MiSeq platform within a longitudinal study framework focused on microbiomes of HAEC patients.尽管通过有效手术恢复肠道动力，先天性巨结肠（Hirschsprung Disease, HSCR）新生儿仍面临极高风险罹患潜在致命且病因未明的小肠结肠炎。近期多项研究提示，肠道菌群可能参与了巨结肠相关性小肠结肠炎（Hirschsprung-associated enterocolitis, HAEC）的潜在发病机制。本数据集采用因美纳（Illumina）MiSeq测序平台，在聚焦HAEC患者肠道微生物组的纵向研究框架下完成相关检测分析。