Structure of E. coli dihydrofolate reductase (DHFR) in an occluded conformation and in complex with a cycloguanil derivative

Structure of E. coli dihydrofolate reductase (DHFR) in an occluded conformation and in complex with a cycloguanil derivative Descriptor: (6S)-1-(4-chlorophenyl)-6-ethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, Dihydrofolate reductase Authors: Berkovich, D.A, Jez, J.M. Deposit date: 2024-08-22 Release date: 2025-02-26 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Expanding the Landscape of Dual Action Antifolate Antibacterials through 2,4-Diamino-1,6-dihydro-1,3,5-triazines. Acs Infect Dis., 11, 2025