Untitled ItemBody Mass Index and Polycystic Ovary Syndrome: A Two-sample Bidirectional Mendelian Randomization Study

<i>Observational studies have shown a link between elevated body mass index (BMI) and the risk of polycystic ovary syndrome (PCOS). While Mendelian randomization (MR) studies in Europeans have suggested a causal role of increased BMI in PCOS, whether the same role is suggested in Asians has yet to be investigated. We used MR studies to infer causal effects using genetic data from East Asian populations.</i><i> </i>

观察性研究已表明，体重指数（Body Mass Index, BMI）升高与多囊卵巢综合征（Polycystic Ovary Syndrome, PCOS）的发病风险存在关联。此前针对欧洲人群开展的孟德尔随机化（Mendelian Randomization, MR）研究提示，BMI升高对PCOS存在因果作用，但该因果效应是否同样存在于亚洲人群中尚待探究。本研究采用孟德尔随机化方法，利用东亚人群的遗传数据，推断BMI升高对PCOS的因果效应。