Regio- and Stereoselective Multisubstituted Enol Ester Synthesis

Regio- and stereoselective cohalogenation of alkynes with NXS (X = Br, I) was achieved, and the stereoselectivity of the resulting alkenes was dependent on the substituent on the alkyne. Cohalogenation and successive cross-coupling gave multisubstituted enol esters in a one-pot process.本研究成功实现了炔烃与N-卤代琥珀酰亚胺（NXS，X=Br、I）的区域选择性及立体选择性共卤化反应；所得烯烃的立体选择性由炔烃上的取代基决定。通过一锅法依次开展共卤化与交叉偶联反应，即可得到多取代烯醇酯类产物。