Gene expression study in aortic intima samples from progeroid mouse models

The main goal of this study was to gain insight into the mechanisms underlying phenotypic changes in endothelial cells during atherosclerosis associated with Hutchinson-Gilford progeria syndrome, a premature aging syndrome. To this end, we performed an RNAseq experiment with aortic intima samples from atheroprone mice with ubiquitous and VSMC-specific progeria expression and their corresponding controls.本研究的核心目标为阐明与哈钦森-吉尔福德早衰综合征（Hutchinson-Gilford Progeria Syndrome，一种早衰综合征）相关的动脉粥样硬化进程中，内皮细胞表型改变的潜在分子机制。为此，我们针对携带全身性及血管平滑肌细胞（VSMC）特异性早衰相关基因表达的易患动脉粥样硬化小鼠的主动脉内膜样本，及其对应的对照组样本，开展了RNA测序（RNAseq）实验。