Ru-Catalyzed Rearrangement of <i>N</i>‑Methyl Isoxazolidines to <i>N</i>–H 1,3‑Oxazinanes: A Strategy of Self-Hydride Transferring Cleavage of N–O Bonds

A strategy of ruthenium-catalyzed self-hydride transferring cleavage of N–O bonds was designed and utilized in a cascade 1,3-dipolar cyclization of alkenes and N-methyl nitrones followed by an N-demethylative rearrangement, furnishing synthetically useful N–H 1,3-oxazinanes.本研究设计并采用了钌催化的N-O键自身氢转移断裂策略，将其应用于烯烃与N-甲基硝酮的串联1,3-偶极环化反应，随后进行N-脱甲基重排，最终得到具有合成应用价值的N-H 1,3-恶嗪烷（1,3-oxazinanes）。