HLA stratified Transmission Disequilibrium Test (TDT).

The top 32 associated SNPs from the results of the HLA stratified analysis. Surrounding genes are defined by either Grail (www.broadinstitute.org/mpg/grail/) or the Genome Browser (http://genome.ucsc.edu/). The low risk group consists of 115 trios and the high risk group of 88 trios. Genotypes were imputed if any of the posterior probabilities were >0.95.Chisq – the value of the TDT test statistic for the transmission counts.Weighted Chisq – based on the transmission counts of the low and high-risk groups. This value is used for ranking the results.T and U – the number of heterozygous parents who transmit the alleles A1 and A2, respectively. T/U – transmission odds based on the expected transmission counts.本研究人类白细胞抗原（Human Leukocyte Antigen, HLA）分层分析结果中排名前32的关联单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）。侧翼基因通过Grail工具（访问网址：www.broadinstitute.org/mpg/grail/）或UCSC基因组浏览器（访问网址：http://genome.ucsc.edu/）进行定义。低风险组包含115个三联家系，高风险组包含88个三联家系。当任意后验概率大于0.95时，将对基因型进行填充操作。卡方值（Chisq）：针对等位基因传递计数的传递不平衡检验（Transmission Disequilibrium Test, TDT）统计量数值。加权卡方值（Weighted Chisq）：基于低、高风险组的等位基因传递计数计算所得，该数值用于对结果进行排序。T与U：分别代表传递等位基因A1与A2的杂合子亲本数量。T/U比值：基于预期传递计数计算得到的传递优势比。