PREDICTION OF PREGNANCY OUTCOMES AND OPTIMIZATION OF TREATMENT TACTICS IN RECURRENT PREGNANCY LOSS ASSOCIATED WITH ANTIPHOSPHOLIPID SYNDROME

Recurrent pregnancy loss (RPL) is a complex and multifactorial condition in obstetrics that significantly affects women's reproductive health and quality of life. Among the acquired causes, antiphospholipid syndrome (APS) plays a leading role due to its strong association with thrombotic and immunological disturbances that impair placental development and function. This thesis is devoted to the study of prognostic factors and the optimization of treatment tactics in women with RPL associated with APS, with the aim of improving maternal and fetal outcomes. The study is based on an integrated clinical and laboratory approach, including the assessment of antiphospholipid antibody profiles, obstetric history, and instrumental monitoring of pregnancy. Special attention is given to the pathophysiological mechanisms of APS, such as hypercoagulability, endothelial dysfunction, and inflammatory processes at the maternal-fetal interface. These mechanisms contribute to adverse pregnancy outcomes, including miscarriage, preeclampsia, intrauterine growth restriction, and preterm birth.复发性流产（Recurrent pregnancy loss, RPL）是产科学领域一类复杂的多因素疾病，可对女性生殖健康与生活质量造成显著不良影响。在其获得性病因中，抗磷脂综合征（Antiphospholipid syndrome, APS）发挥主导作用，因其与损伤胎盘发育及功能的血栓性、免疫紊乱存在强关联。本论文致力于探究合并APS的RPL患者的预后因素，并优化其治疗策略，以期改善母婴妊娠结局。本研究采用整合性临床与实验室研究方法，涵盖抗磷脂抗体谱评估、产科病史采集以及妊娠的仪器监测。研究重点关注APS的病理生理机制，包括高凝状态、内皮功能障碍以及母胎界面的炎症过程。上述机制可引发多种不良妊娠结局，包括流产、子痫前期、宫内生长受限及早产。