Pan-pediatric cancer alternative splicing regulation and splicing-derived neoantigen atlas — source data and code

Source data, result tables, and complete analysis code for the manuscript "A pan-pediatric cancer atlas of alternative splicing regulation and splicing-derived neoantigens" (Cancer Research and Treatment). The deposit contains: the streaming rMATS catalog of 434,755 alternative splicing events across 4,124 pediatric RNA-sequencing samples (OpenPedCan release v15, every source file verified against the release md5 manifest); the validated 211-factor splicing-factor catalog with per-histology restriction calls; the spliceosome mutation catalog (2,628 specimens; U2AF1 rows are flagged as uninterpretable owing to the GRCh38 chr21p reference artifact); the junction-peptide catalog (1,341 event-peptide pairs) with all 34,290 peptide-allele MHC-I predictions; junction-level normal-tissue detectability of every peptide-producing event against the GTEx v8 junction read-count matrix (17,382 transcriptomes); pediatric-versus-adult comparisons with library-matched sensitivity analyses; the frame-anchored candidate sensitivity ranking; and the DepMap dependency and factor-level priority tables. Complete pipeline source code, per-figure code, run logs, and manuscript LaTeX source are included. Per-file SHA-256 checksums are provided (checksums.sha256).