<i>cis</i>-2,5-Diaminobicyclo[2.2.2]octane, a New Scaffold for Asymmetric Catalysis via Salen−Metal Complexes

A new C2 symmetric salen scaffold based on cis-2,5-diaminobicyclo[2.2.2]octane has been synthesized that forms complexes with a wide range of metals. The chromium(III) complex is shown to catalyze the hetero-Diels−Alder reaction and the Nozaki−Hiyama−Kishi reaction with high efficiency and excellent stereoselectivity.本研究合成了一种基于顺式-2,5-二氨基双环[2.2.2]辛烷的新型C2对称salen配体（salen）骨架，该骨架可与多种金属形成配合物。实验表明，其铬(III)配合物可高效催化杂-Diels−Alder反应与野崎-桧山-岸反应，且具有优异的立体选择性。