European_wide_survey_of_carbapenem__and_or_colistin_resistant_Enterobacteriaceae

This study will use whole genome sequencing (WGS) data from Klebsiella pneumoniae and Escherichia coli isolates collected during the 2019 European-wide survey of carbapenem- and/or colistin-resistant Enterobacteriaceae. Isolates were collected from hospitals and their associated clinical microbiology laboratories in 37 countries during a six-month period. Both resistant and comparator susceptible isolates were collected. The WGS data will be used to analyse the population structure, with particular emphasis on the identification of high-risk clones. It will also be used to determine the prevalence, distribution and transmission dynamics of key resistance and virulence markers.本研究将使用2019年欧洲范围内碳青霉烯类（carbapenem）及/或黏菌素（colistin）耐药肠杆菌科（Enterobacteriaceae）菌株普查中采集的肺炎克雷伯菌（Klebsiella pneumoniae）与大肠埃希菌（Escherichia coli）分离株的全基因组测序（WGS）数据。该批分离株于6个月周期内，从37个国家的医院及其附属临床微生物实验室完成采集。本次采集同时涵盖耐药菌株与对照敏感菌株。上述全基因组测序数据将用于解析菌株种群结构，重点聚焦高风险克隆株的识别工作，同时还将用于明确关键耐药与毒力标记物的流行率、分布特征及传播动态。