LL-37 instillation leads to local and systemic inflammatory changes and GM-0111 reduces the inflammatory effects of LL-37.
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The animals treated with LL-37 show decreased body weight gain (A), increased bladder weight (B), gross anatomical changes in the bladder (C), severity of inflammatory changes in histological observations (D), and the bladder concentration of IL-6 (E), PTX-3 (F), MPO activity (G) and blood level of SAP (H). *ppp
经LL-37处理的动物表现出以下变化:体重增重降低(A)、膀胱重量升高(B)、膀胱大体解剖学改变(C),组织学观察显示炎症病变严重程度加剧(D),且膀胱组织内白细胞介素6(IL-6)、正五聚蛋白3(PTX-3)的浓度、髓过氧化物酶(MPO)活性(E、F、G)以及血液中血清淀粉样P成分(SAP)的水平(H)均出现相应改变。*ppp
创建时间:
2016-02-23



