Microglial NLRC5 Drives Lysosomal Dysfunction to Disrupt Autophagic Flux and Promote Post-Stroke Neuroinflammation

To further elucidate the molecular mechanisms by which microglial NLRC5 exacerbates post-stroke inflammation, we performed proteomic profiling of primary microglia isolated from WT and Nlrc5 KO mice following OGD/R treatment.为进一步阐明小胶质细胞NLRC5加剧卒中后炎症的分子机制，我们对从野生型（Wild Type, WT）和Nlrc5基因敲除（Knockout, KO）小鼠中分离得到的原代小胶质细胞，在经氧糖剥夺/复氧（Oxygen Glucose Deprivation/Reperfusion, OGD/R）处理后进行了蛋白质组学分析。