Efficient Assembly of Polysubstituted Pyrroles via a (3 + 2) Cycloaddition/Skeletal Rearrangement/Redox Isomerization Cascade Reaction

An unprecedented cascade strategy, used in conjunction with a redox isomerization, for the synthesis of 3-allyl pyrroles is reported. In a single step, readily accessible simple starting materials are transformed into highly substituted pyrroles with high efficiency. The products obtained contain allyl substituents, which can be readily elaborated to other useful functional groups. The reaction proceeds through an unusual (3 + 2) cycloaddition/skeletal rearrangement/redox isomerization pathway.本研究报道了一种结合氧化还原异构化（redox isomerization）的全新级联策略，用于3-烯丙基吡咯的合成。该方法可通过单步反应，将易于获取的简单起始原料高效转化为高取代吡咯类化合物。所得到的产物带有烯丙基取代基，该取代基可进一步衍生化为其他实用的官能团。该反应经由一条非常规的(3+2)环加成/骨架重排/氧化还原异构化反应路径进行。