Gallium Analogue of Soluble Prussian Blue KGa[Fe(CN)6]·nH2O: Synthesis, Characterization, and Potential Biomedical Applications

The gallium analogue of the soluble Prussian blue with the formula KGa­[Fe­(CN)6]·nH2O is synthesized and structurally characterized. A simple aqueous synthetic procedure for preparing nanoparticles of this novel coordination polymer is reported. The stability, in vitro ion exchange with ferrous ions, cytotoxicity, and cellular uptake of such nanoparticles coated with poly­(vinylpyrrolidone) are investigated for potential applications of delivering Ga3+ ions into cells or removing iron from cells.本研究合成了化学式为KGa[Fe(CN)₆]·nH₂O的可溶性普鲁士蓝镓类似物，并完成了结构表征。本研究报道了一种制备该新型配位聚合物纳米颗粒的简便水相合成方法。针对聚乙烯吡咯烷酮（poly(vinylpyrrolidone)）包覆的此类纳米颗粒，本研究对其稳定性、与亚铁离子的体外离子交换性能、细胞毒性及细胞摄取行为展开了考察，以期探究其在向细胞内递送Ga³+离子或从细胞中移除铁元素领域的潜在应用价值。