REHABILITATION THERAPY WITH INSULIN-LIKE GROWTH FACTOR AFTER ACUTE SKELETAL MUSCLE INJURY

ABSTRACT Introduction Skeletal muscle injuries account for 10% to 50% of treadmill sports injuries. Insulin-like growth factor (IGF) is a family of polypeptides with both insulin-like anabolic and growth-promoting effects. Sports play a vital role in the recovery of skeletal muscle injuries. Objective The paper analyzes the ability of insulin-like growth factor 1 (IGF-1) to repair skeletal muscle injury caused by treadmill exercise. Method We injected drugs under the wound after exercise-induced injury in rats. The control group was injected with saline, and the experimental group was injected with an insulin-like growth factor. We conduct histological and electron microscopic structural analysis of rats, Results: After an injury, the experimental group formed a basal lamina protective film earlier than the control group, activated myoblasts, formed myofilaments, formed myotubes, and fused into muscle fibers earlier than the control group. The healing quality was also better. The experimental group was endogenous. The mRNA content of sex IGF-1 and IGF-2 both increased earlier than the control group. Conclusion Local injection of exogenous insulin-like growth factor-1 can stimulate the proliferation of myoblasts and accelerate the post-traumatic repair process of skeletal muscle caused by treadmill sports. Level of evidence II; Therapeutic studies - investigation of treatment results.摘要 引言 骨骼肌损伤占跑步机运动损伤的10%至50%。胰岛素样生长因子（insulin-like growth factor, IGF）是一类兼具胰岛素样合成代谢活性与促生长效应的多肽家族。运动对于骨骼肌损伤的修复具有关键作用。 研究目的：本研究旨在分析胰岛素样生长因子1（insulin-like growth factor 1, IGF-1）修复跑步机运动诱导的骨骼肌损伤的能力。 研究方法：我们对运动诱导损伤的大鼠实施创面下药物注射。对照组予以生理盐水注射，实验组则注射胰岛素样生长因子。随后对大鼠开展组织学与电子显微镜结构分析。 研究结果：损伤发生后，实验组较对照组更早形成基底膜保护膜，激活成肌细胞、生成肌丝、构建肌管并融合为肌纤维，且损伤愈合质量更优。实验组内源性胰岛素样生长因子1与2的mRNA表达量均较对照组更早升高。 研究结论：局部注射外源性胰岛素样生长因子-1可刺激成肌细胞增殖，加速跑步机运动所致骨骼肌损伤后的创伤修复进程。 证据等级为Ⅱ级；治疗性研究——治疗效果调查。