Mutation rates to ciprofloxacin resistance^a.

aMutation rates (µ) per replication and 95% confidence limits (CL) were calculated as described in Material and Methods. Mutation rates for the WT and mutator (mutS, mutT, mutY and mutM) strains were calculated at 1.0 µg/ml Cip. Assays with 2-aminopurine (2AP), cisplatin (CPT) and hydrogen peroxide (HP) were performed at 0.5 µg/ml Cip. bMutation rates calculated for the WT strain at each set of experiment (mutator strain and mutagen assessment) were used for data normalization.a 每轮复制的突变率（µ）及95%置信限（CL）均按照《材料与方法》中的描述进行计算。野生型（WT，Wild Type）与突变型（mutS、mutT、mutY及mutM）菌株的突变率均在1.0 μg/ml环丙沙星（Cip）条件下测算得到。采用2-氨基嘌呤（2-aminopurine，2AP）、顺铂（cisplatin，CPT）与过氧化氢（hydrogen peroxide，HP）的检测实验均在0.5 μg/ml环丙沙星（Cip）条件下开展。b 针对每组实验（突变株构建与诱变剂评估实验）中野生型菌株测算得到的突变率，被用于数据归一化处理。