Cell-type specific translational changes in prion diseases

Identification of genome-wide translational changes during prion disease via cell-type specific ribosome profiling. Mice expressing GFP-tagged ribosome in prion disease relevant cell types were inoculated with non-infectious brain homogenate or prions and sacrificed at different time points during disease progression.本数据集通过细胞类型特异性核糖体谱（ribosome profiling）技术，鉴定朊病毒病病程中的全基因组翻译变化。将在朊病毒病相关细胞类型中表达绿色荧光蛋白（GFP）标记的核糖体的小鼠，分别接种非感染性脑组织匀浆或朊病毒，并在疾病进展的不同时间点实施安乐死。