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Psoriasis is a chronic, immune-mediated inflammatory skin disease, and the inflammatory response plays an important role in its development and progression. Psoriasis can appear at any age and occurs around the world. The pathogenesis of psoriasis has not been fully elucidated, and there is currently no effective treatment method in clinical practice. Broussonetia papyrifera is a traditional Chinese medicine that exhibited a significant therapeutic effect on psoriasis in our previous study due to its remarkable anti-inflammatory and anti-oxidant properties. However, its mechanism of action in treating psoriasis is still unclear. The purpose of this study is to evaluate the anti-psoriasis effect of the B. papyrifera leaves extract (PLE) in vivo and to explore its potential effects. PLE effectively alleviated imiquimod (IMQ)-induced psoriasis-like lesions, reduced psoriasis lesion area and severity index, decreased epidermal hyperplasia, ameliorated the oxidative stress-induced changes in the levels of superoxide dismutase (SOD) and malondialdehyde (MDA), and reduced the levels of the inflammatory cytokines TNF-α and IL-17A. PLE can also reduce the protein expression levels of TLR4, MyD88, p-NF-κBp65, p-IκBα, p-PI3K and p-AKT induced by IMQ model. Our findings suggest that PLE is effective in improving psoriasis-like symptoms, which might be ascribed to the inhibition of the TLR4/NF-κB and PI3K/AKT inflammation pathway. Our study demonstrates the potential mechanism of a natural source of PLE for the treatment of psoriasis. However, it is important to note that these findings lack clinical validation, and further studies are required to validate these results in clinical settings. Additionally, PLE shows potential in being a cost-effective alternative compared to existing biologics, which could have broader implications for psoriasis treatment in the future.银屑病是一种慢性免疫介导性炎症性皮肤病，炎症反应在其发生发展过程中发挥关键作用。该病可发生于任何年龄段，全球范围内均有分布。目前银屑病的发病机制尚未完全阐明，临床暂无特效治疗方案。楮树（Broussonetia papyrifera）是一味传统中药，本课题组前期研究证实，其凭借卓越的抗炎与抗氧化活性，对银屑病具有显著治疗效果，但其用于治疗银屑病的具体作用机制仍未明确。本研究旨在体内评估楮树叶提取物（PLE）的抗银屑病作用，并探究其潜在作用。结果显示，PLE可有效缓解咪喹莫特（IMQ）诱导的银屑病样皮损，降低银屑病皮损面积与严重程度指数，减轻表皮增生；同时可改善氧化应激诱导的超氧化物歧化酶（SOD）与丙二醛（MDA）水平异常，下调炎症细胞因子肿瘤坏死因子-α（TNF-α）及白细胞介素-17A（IL-17A）的表达水平。此外，PLE还可抑制IMQ模型中上调的Toll样受体4（TLR4）、髓系分化因子88（MyD88）、磷酸化核因子-κB p65（p-NF-κBp65）、磷酸化IκBα（p-IκBα）、磷酸化磷脂酰肌醇3-激酶（p-PI3K）及磷酸化AKT（p-AKT）的蛋白表达水平。本研究结果表明，PLE可有效改善银屑病样症状，其作用机制可能与抑制TLR4/NF-κB及PI3K/AKT炎症通路密切相关。本研究阐明了天然来源的PLE治疗银屑病的潜在作用机制，但需注意的是，上述发现尚未经过临床验证，仍需开展后续临床研究以在临床场景中证实该结果。此外，相较于当前临床使用的生物制剂，PLE具备成为高性价比治疗替代方案的潜力，未来有望为银屑病治疗带来更广阔的应用前景。