Solar UVR and exosomal miRNAs effect pre-mature senescence in melanocytes [microarray]

The selection of specific miRNAs by exosomes and their release from cultured melanocytes after exposure to solar UVR (UVA+UVB) have activities in inducing these cells into a premature senescence. In this analysis, Affymetrix's GeneChip miRNA 4.0 array was used to measure changes in the levels of miRNAs in exosomes from un-irradiated and irradiated melanocytes外泌体（exosomes）对特定微小RNA（miRNAs）的分选，以及培养的黑素细胞（melanocytes）在暴露于太阳紫外线辐射（solar UVR，UVA+UVB）后释放此类微小RNA的过程，均可诱导这些细胞发生早衰。本分析采用Affymetrix公司的GeneChip miRNA 4.0基因芯片，检测未照射及经紫外线照射的黑素细胞来源外泌体中微小RNA的水平变化。