The 29 novel associated MS risk genes.

RAF: risk allele frequency, OR: odds ratio, 95% CI: 95% confidence interval.OR and p-value represent the combined discovery and replication study results [9]. Risk allele frequency refers to allele frequency in control population of UK samples.Reprinted by permission from Macmillan Publishers Ltd: The International Multiple Sclerosis Genetics Consortium and The Wellcome Trust Case Control Consortium. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 2011, Nature 476: 214–219.RAF（风险等位基因频率，risk allele frequency）、OR（比值比，odds ratio）与95% CI（95%置信区间，95% confidence interval）。其中OR值与P值代表了发现研究与重复验证研究的合并分析结果[9]。此处的风险等位基因频率指英国样本对照群体中的等位基因频率。本文经麦克米伦出版有限公司（Macmillan Publishers Ltd）授权转载，来源为国际多发性硬化症遗传学联合会（The International Multiple Sclerosis Genetics Consortium）与威康信托病例对照联合会（The Wellcome Trust Case Control Consortium），论文题目为《多发性硬化症的遗传风险及细胞介导免疫机制的核心作用》，发表于2011年《自然》（Nature）第476卷，第214–219页。