Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer (Microarray)

This study investigates the transcriptome of primary dermal lymphatic endothelial cells compared with blood vascular endothelial cells using samples isolated from wildtype embryos at defined points (E14.5, E16.5 and E18.5) during mouse embryonic development. Matching LEC and BEC samples from three litters (independent biological replicates) at each timepoint are compared by RNA microarray analysis.本研究针对小鼠胚胎发育过程中既定时间点（胚胎发育第14.5天、第16.5天及第18.5天，即E14.5、E16.5、E18.5）分离的野生型胚胎样本，对比原代皮肤淋巴内皮细胞（primary dermal lymphatic endothelial cells）与血管内皮细胞（blood vascular endothelial cells）的转录组（transcriptome）。各时间点下，取自3窝独立生物学重复的淋巴内皮细胞（LEC）与血管内皮细胞（BEC）配对样本，通过RNA微阵列分析（RNA microarray analysis）开展对比分析。