Simple <i>N</i>-Sulfinyl-Based Chiral Sulfur–Olefin Ligands for Rhodium-Catalyzed Asymmetric 1,4-Additions

A variety of N-sulfinyl-based chiral sulfur–olefin ligands has been successfully developed for the first time for rhodium-catalyzed highly efficient and enantioselective 1,4-additions. The ease of synthesis and needless consideration of the carbon chirality makes this novel type of ligands attractive for asymmetric catalysis.本研究首次成功开发了一系列基于N-亚磺酰基（N-sulfinyl）的手性硫-烯烃配体，用于铑催化的高效对映选择性1,4-加成反应。该类配体合成简便，且无需考量碳手性中心，因而这类新型配体在不对称催化领域具备显著的应用潜力。