Upregulation of pro-apoptotic microRNA mir-125a following massive small bowel resection in rats

Upregulation of mir-125a suppresses the pro-survival protein Mcl1, producing the increase in apoptosis known to accompany the proliferative changes characteristic of intestinal adaptation. Our data highlight a potential role for microRNAs as mediators of the adaptive process and may facilitate the development of new therapeutic options for short bowel syndrome.微小RNA-125a（mir-125a）的上调可抑制促存活蛋白髓系细胞白血病因子1（Mcl1），进而引发细胞凋亡水平升高，该凋亡变化是学界已知的、伴随肠道适应特征性增殖改变的现象。本研究数据揭示了微小RNA（microRNAs）作为肠道适应过程介导因子的潜在作用，或可推动短肠综合征新型治疗方案的开发。