DrugCVar

In our study, we provide the DrugCVar database, which integrated our manually curated cancer variant-drug targeting evidence from literature and the interpretations from the public resources. In total, 8,539 clinical evidence for cancer variant-drug targeting were integrated and classified into ten evidence tiers. Searching and browsing functions were provided for quick queries of cancer variant-drug targeting evidence. Also, batch annotation was developed for user-provided massive genetic variants in various formats.本研究中，我们提供了DrugCVar数据库，该库整合了我们从文献中人工审校的癌症变异-药物靶向证据，以及公共资源提供的解读结果。本库共计整合了8539条癌症变异-药物靶向临床证据，并将其划分为十个证据等级。数据库配备了检索与浏览功能，可快速查询癌症变异-药物靶向证据。此外，还开发了批量注释功能，可对用户提供的多种格式的海量遗传变异进行注释。

搜集汇总

背景与挑战

背景概述

DrugCVar是一个专注于癌症变异-药物靶向证据的数据库，整合了8,539条临床证据并分为十个证据等级。它提供搜索、浏览和批量注释功能，旨在支持精准医疗中针对大量癌症变异的药物解读。