Direct Asymmetric Vinylogous Mannich Reaction of 3,4-Dihalofuran-2(5H)‑one with Aldimine Catalyzed by Quinine
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The direct asymmetric vinylogous Mannich reaction of 3,4-dihalofuran-2(5H)-one with aldimine catalyzed by quinine was first reported, and γ-butenolides have been obtained in excellent yield (up to 98%) and enantioselectivities (up to 95% ee). The synthetic applications of this protocol are demonstrated in the preparations of γ-substituted amino butyrolactones and vicinal amino alcohols.
创建时间：
2016-02-20
