Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib
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Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib Descriptor: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J. Deposit date: 2021-03-11 Release date: 2021-04-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.09 Å) Cite: Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc.Natl.Acad.Sci.USA, 118, 2021
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2021-03-11
