The non-canonical pathway engaged by members of the TNF-like family of cytokines is responsible for the activation of p100/RelB complexes and occurs during the development of lymphoid organs responsib
The canonical NF-KB pathway is induced by the ligand-dependent activation of a variety of receptors. Stimulus-dependent activation of the IKK complex results in the phosphorylation and subsequent prot
The NF-kB family of transcription factors plays important roles in the immune system. Two signaling pathways lead to the activation of NF-kB, known as the classical (canonical) pathway and the non-can